About Us
By combining expertise in chemistry and biology BFC group aim to develop first hybrid biosynthetic living systems using dynamic and adaptive interactions of chemical and biological systems.
Toward this end we search for reactions and catalysts capable of reacting specifically with define biocomponents (proteins, metabolites, sugars…) in their native environments. Such systems should allow for example in vivo site-specific bioconjugation of a target protein, in vivo neutralization of endogenous or exogenous bioactive molecule or actuation of living organism via catalytic regulation of metabolic abnormalities.
Toward this end we search for reactions and catalysts capable of reacting specifically with define biocomponents (proteins, metabolites, sugars…) in their native environments. Such systems should allow for example in vivo site-specific bioconjugation of a target protein, in vivo neutralization of endogenous or exogenous bioactive molecule or actuation of living organism via catalytic regulation of metabolic abnormalities.
Highlighted Publications
An in vivo strategy to counteract post-administration anticoagulant activity of azido-Warfarin
Nature Communication, 2017 |
Acyl Fluorides: Fast, Efficient, and Versatile Lysine-Based Protein Conjugation via Plug-and-Play Strategy
Bioconjugate Chemistry, 2017 |
Partners
ProFI
Proteomic French Infrastructure |
IBITECS (CEA)
Laboratoire de Marquage au Carbone 14 |
LSMBO
Laboratoire de Spectrométrie de Masse BioOrganique |
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