15/09/2023 - [New Publication ! ]
Congratulations to Ilias Koutsopetras and all the person involved in this work related with hypervalent iodine (III) molecules. The so-called EBZ reagents are N-analogues of EBX and have been now used for the first-time for biomolecule functionalization. They enable multiple reversible cross-linking between cysteines by combining nucleophilic aromatic substitution, hypervalent iodine and azide reactivity in a single reagent, with applications ranging from peptide modification to antibody rebridging.
Follow this link to read the paper : https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202302689?af=R
Follow this link to read the paper : https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202302689?af=R
13/09/2023 - [New Publication !]
Congratulations to Robin Dufossez and everyone involved on this new work on the surface functionnalisation of droplets in microfluidics. This study observed the influence of the azido-bearing head of the surfactant on their ability to react via SPAAC with DBCO-modified antibodies to decorate the inner surface of droplets. We also studied how the hydrophilic head structure acted on the stability of the droplets, and how the droplets' functionnalization by antibodies enhance their stability.
Don't hesitate to read the paper: https://pubs.acs.org/doi/10.1021/acsami.3c10655?fig=abs1&ref=pdf
Don't hesitate to read the paper: https://pubs.acs.org/doi/10.1021/acsami.3c10655?fig=abs1&ref=pdf
21/08/2023 - [New publication ! ]
Congratulations to Victor Lehot , Patrick Neuberg, Manon Ripoll, Igor Dovgan, Sylvain Ursuegui, Antoine Kichler, Guilhem Chaubet, Alain Wagner and all the persons involved in this project.
The publication is about the development of a new family of toxic payloads based on the inherent toxicity of cationic nanoparticles in Antibody-Toxic-Nanoparticles Conjugates (ATNPs) system.
Read the paper on : www.mdpi.com/1999-4923/15/6/1643
The publication is about the development of a new family of toxic payloads based on the inherent toxicity of cationic nanoparticles in Antibody-Toxic-Nanoparticles Conjugates (ATNPs) system.
Read the paper on : www.mdpi.com/1999-4923/15/6/1643
11/05/2023 - [Congratulations Julien!]
Congratulations to Julien Most who passed his PhD defense successfully in front of a jury composed of Pr. Emilie Allard-Vannier,
Pr. Franck Denat, Pr. Alexandre Detappe and Dr Hervé Bouchard !
We are really proud of him and wish him the best for his future career !
Pr. Franck Denat, Pr. Alexandre Detappe and Dr Hervé Bouchard !
We are really proud of him and wish him the best for his future career !
09/05/2023 - [Congratulations Guilhem Chaubet !]
Congratuations to Guilhem Chaubet winner of the JCJC prize SCF-Chembio 2023 ! He will have the opportunity to make an oral communication at the SCF2023 congress which will take place in Nantes from June 26 to 28, 2023.
https://new.societechimiquedefrance.fr/groupes/groupe-de-chemobiologie/prixjcjc/
22/03/2023 - [New publication ! ]
Congratulations to Robin Dufossez, Ketty Pernod, Safae Mouftakhir, Guilhem Chaubet, Alain Wagner and all the persons involved on this publication about the development of a functionalized fluorosurfactant for a new particles free immunoassay method in droplet based microfluidics. This azido-functionalized surfactant can react via SPAAC with BCN-modified antibodies to decorate the inner surface of droplets. We showed that these antibodies can capture targeted proteins and lead to the subsequent relocalisation at the surface of labeled detection antibodies, thus forming a specific detection signal.
Don't hesitate to read the paper: https://pubs.acs.org/doi/10.1021/acs.analchem.2c05168
16/03/2023 - [Good retirement Isabelle ! ]
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After so many years with us as a Biological engineer and prevention officer, Isabelle will leave us to enjoy her retirement We wish her the best ! |
13/03/2023 - [Welcome !]
We are happy to welcome Ida Staccioni and Amélie Leroux (University of Strasbourg), our news trainees !
They will work on the synthesis of surfactants and cleavable linkers !
Good luck !
They will work on the synthesis of surfactants and cleavable linkers !
Good luck !
07/02/2023 - [Discover an interview of Alain, Mouad Alami, Julien Nicolas and Sébastien Papot about the futur of targeted therapies!]
CNRS has published an interview of Alain Wagner, Mouad Alami, Julien Nicolas and Sébastien Papot about the futur of targeted therapies !
In this interview, the researchers explain their works and their opinions to improve actual treatments against cancers ! They discuss about different way to increase patients quality of life by the elaboration of new methods such as vectorization, Antibody-drug conjugates, stable drugs, synthetic's prodrugs, nanoparticles or combined approaches against resistant cancers.
If you're interested, don't hesitate to click on the following link to discover this interview (in French):
https://lejournal.cnrs.fr/nos-blogs/de-la-decouverte-a-linnovation/contre-le-cancer-des-traitements-cibles-en-ligne-de-mire
In this interview, the researchers explain their works and their opinions to improve actual treatments against cancers ! They discuss about different way to increase patients quality of life by the elaboration of new methods such as vectorization, Antibody-drug conjugates, stable drugs, synthetic's prodrugs, nanoparticles or combined approaches against resistant cancers.
If you're interested, don't hesitate to click on the following link to discover this interview (in French):
https://lejournal.cnrs.fr/nos-blogs/de-la-decouverte-a-linnovation/contre-le-cancer-des-traitements-cibles-en-ligne-de-mire
01/02/2023 - [Interdisciplinarity between chemistry and biology]
Are you interested about interdisciplinarity ?
It's the case for Julien and Agathe who work together to develop new synergestic therapy to treat resistance cancers ! By mixing their knowledges and their skills in chemistry and biology, they are working on the same innovative project !
You can discover an interview (in French) of our passionate PhD students on the following link :
https://savoirs.unistra.fr/talents/interdisciplinarite-chimie-et-biologie-sallient-contre-le-cancer
It's the case for Julien and Agathe who work together to develop new synergestic therapy to treat resistance cancers ! By mixing their knowledges and their skills in chemistry and biology, they are working on the same innovative project !
You can discover an interview (in French) of our passionate PhD students on the following link :
https://savoirs.unistra.fr/talents/interdisciplinarite-chimie-et-biologie-sallient-contre-le-cancer
13/12/2022 - [Congratulations Enes!]
Congratulations to Enes Dursun who passed his PhD defense successfully in front of a jury composed of Dr Marie Lopez,
Dr Vangelis Agouridas, Prof. Michael Smietana and Dr Vincent Cura !
We are really proud of him and wish him the best for his future career !
Dr Vangelis Agouridas, Prof. Michael Smietana and Dr Vincent Cura !
We are really proud of him and wish him the best for his future career !
07/11/2022 - [Meet Alain at the 14th & 15th URA International Seminar - Japan]
Meet Alain on November 10th & 14th at the 14th & 15th URA International Seminar at the Okayama University in Japan !
On the 10th (Shikata Campus), he will give a talk about new Antibody-based drug delivery systems. He will explain our studies about the improvement of ADCs by increasing bioconjugation efficiency and by controlling payload release. He will also introduce main highlights of recent advances in synthesis and evaluation of antibody-RNA conjugates and multi-mode of action ADCs allowing synergies tic targeted cytotoxic activity and immune system stimulation.
On the 14th (Tsushima), he will give a talk about Interfacing Chemistry and Microfluidics. He will expain the development of advanced generation of technologies opening-up quantification of single cell at their proteome and metabolome level.
On the 10th (Shikata Campus), he will give a talk about new Antibody-based drug delivery systems. He will explain our studies about the improvement of ADCs by increasing bioconjugation efficiency and by controlling payload release. He will also introduce main highlights of recent advances in synthesis and evaluation of antibody-RNA conjugates and multi-mode of action ADCs allowing synergies tic targeted cytotoxic activity and immune system stimulation.
On the 14th (Tsushima), he will give a talk about Interfacing Chemistry and Microfluidics. He will expain the development of advanced generation of technologies opening-up quantification of single cell at their proteome and metabolome level.
24/10/2022 - [Meet Alain at the BIO-Europe - Leipzig]
Meet Alain on October 24-26th at the BIO-Europe in Leipzig (Germany) !
He will give a talk about our newest Start-up MicroOmix, secretion based single cell analysis and sorting !
For more informations, don't hesitate to click on the following link :
https://informaconnect.com/bioeurope/?utm_source=ingo&utm_medium=social+post&utm_campaign=BEU&ingo_user_id=15456695
He will give a talk about our newest Start-up MicroOmix, secretion based single cell analysis and sorting !
For more informations, don't hesitate to click on the following link :
https://informaconnect.com/bioeurope/?utm_source=ingo&utm_medium=social+post&utm_campaign=BEU&ingo_user_id=15456695
03/10/2022 - [WELCOME!]
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We are happy to welcome Louis Moreira Da Silva (University of Poitier), our new PhD student ! He is in collaboration with the team of Jérôme BECKER from the University of Tours ! He will work on nanobodies bioconjugation to develop new targeted treatment ! Good luck ! |
23/09/2022 - [Meet Alain at the Single-Cell Analysis Conference - London]
Meet Alain on October 6th at the Single-Cell Analysis Conference UK/EU Edition in London !
He will give a talk about Secretion based single cell analysis and sorting !
For more informations, don't hesitate to click on the following link :
https://events.marketsandmarkets.com/marketsandmarkets-single-cell-analysis-conference-uk-eu-edition/register
23/06/2022 - [Congratulations to Agathe and Julien!]
Congratulations to Agathe and Julien for winning the 2022 Mature Your PhD Challenge organized by the Satt Conectus !
They will benefit from personalized support from experts of Satt Conectus to discover some marketing and intellectual property aspects linked to their project ! They also will have access to entrepreneurship formations in collaboration with the Semia incubator, and they will have the possibility to obtain a post-doctoral grant to continue the development of their project until the market !
You can follow them and have more informations on following links :
https://www.conectus.fr/challenge-mature-phd-2022-5-doctorantes-laureates
https://www.linkedin.com/posts/satt-conectus_challenge-mature-phd-2022-5-doctorantes-activity-6945650994533814272-F2os?utm_source=linkedin_share&utm_medium=member_desktop_web
https://twitter.com/ConectusAlsace/status/1539973281016451072?s=20&t=vXXpStsDVLFAIpDFlO-byA
They will benefit from personalized support from experts of Satt Conectus to discover some marketing and intellectual property aspects linked to their project ! They also will have access to entrepreneurship formations in collaboration with the Semia incubator, and they will have the possibility to obtain a post-doctoral grant to continue the development of their project until the market !
You can follow them and have more informations on following links :
https://www.conectus.fr/challenge-mature-phd-2022-5-doctorantes-laureates
https://www.linkedin.com/posts/satt-conectus_challenge-mature-phd-2022-5-doctorantes-activity-6945650994533814272-F2os?utm_source=linkedin_share&utm_medium=member_desktop_web
https://twitter.com/ConectusAlsace/status/1539973281016451072?s=20&t=vXXpStsDVLFAIpDFlO-byA
13/05/2022 - [Happy birthday MicroOmix!]
Today is a special day !
Today MicroOmix, our newest start-up, celebrates his first year after his creation ! A entire year of successful HTS secretion-based single cell, analysis, sorting and recovery !
Happy birthday MicroOmix !
Today MicroOmix, our newest start-up, celebrates his first year after his creation ! A entire year of successful HTS secretion-based single cell, analysis, sorting and recovery !
Happy birthday MicroOmix !
26/04/2022 - [Meet Guilhem at the ICMUB - University of Dijon!]
Meet Guilhem at the ICMUB (University of Dijon) on 29th April 2022 !
We will give a talk about chemo- and regio-selective approaches for the chemical conjugation of native proteins !
We will give a talk about chemo- and regio-selective approaches for the chemical conjugation of native proteins !
25/04/2022 - [Meet Agathe and Julien at the 2nd IMS public scientific meeting!]
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Meet Agathe and Julien at the 2nd IMS public scientific meeting at the IPHC (Campus Cronenbourg) on 28th April 2022 ! They will present their experiences about the DDD challenge organized by the IMS and their strategy for the development of a new therapeutic tool against cancer stem-like cells ! https://ims.unistra.fr/journee-scientifique-de-lims/ |
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04/04/2022 - [WELCOME!]
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Welcome to our new PhD student, Indréalie Lantus (ESCOM - University of Compiègne, UPJV - University of Amiens)! She is in collaboration with Sanofi and she will work on the developpment of new linkers for bioconjugation application! Good luck! |
15/03/2022 - [Meet Alain at the Biologics UK - London]
Meet Alain on March 21th and 22th at Biologics UK in London !
He will give a talk about our newest Start-Up MicroOmix and its technologies for HTS secretion-based single cell, analysis, sorting and recovery !
For more informations, don't hesitate to click on the following links :
https://www.oxfordglobal.co.uk/biologics-series/
https://lnkd.in/eZzbrHMp
07/03/2022 - [WELCOME!]
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We are happy to welcome Ala Covas (University of Strasbourg), our new trainee ! She will work on SPAAC optimization for bioconjugation based multicomponent reactions methods ! Good luck ! |
27/01/2022 - [NEW PUBLICATION!]
Congratulations to Charlotte Sornay, Valentine Vaur, Alain Wagner and Guilhem Chaubet for the publication of a new review in the Royal Society Open Science journal !
This review gives a historical overview of the challenges in selectivity associated with the chemical conjugation of protein and shows that bioconjugation is an exciting growing field for synthetic chemists !
Don't hesitate to read the paper : https://royalsocietypublishing.org/doi/10.1098/rsos.211563
13/01/2022 - [CONGRATULATIONS!]
Congratulation to our spin off company Syndivia and TVM Capital Life Science for the creation of Auricula Biosciences.
Their goal is to develop a conjugate that targets macropinocytosis, a unique feature of cancer cells harboring K-Ras mutations.
If you are interested to learn more, don't hesitate to read the following articles:
https://lnkd.in/gd-Hxidc
https://lnkd.in/gHrcAHDn
Their goal is to develop a conjugate that targets macropinocytosis, a unique feature of cancer cells harboring K-Ras mutations.
If you are interested to learn more, don't hesitate to read the following articles:
https://lnkd.in/gd-Hxidc
https://lnkd.in/gHrcAHDn
10/01/2022 - [WELCOME!]
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We are happy to welcome Léa Rochet, a PhD student from the team of Prof. Vijay Chudasama at the UCL (England)! She is part of the TACT-ETN project and will work on the development of new bioconjugation methods using multicomponent reactions ! She will stay with us for a three-months period time! |
10/12/2021 - [Congratulations Tony!]
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Congratulations to Tony Rady who passed his PhD defense successfully in front of a jury composed of Dr Nicolas Joubert, Prof. David Spring and Prof. Jean-Luc Imler ! We are really proud of him and wish him the best for his future career |
30/11/2021 - [Meet Ketty, Agathe and Julien at the Biotech Day - ESBS!]
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Meet Ketty, Agathe and Julien at the Biotech Day at the ESBS on December 2nd 2021 ! Learn more on the next generation single-cell tools with the presentation of MicroOmix ! Ketty, our engineer will give you his feedback and his transition from public research to start-up ! Want to discover the DDD Challenge ? Agathe and Julien will present their experiences about this challenge organized by the IMS and their strategy for the development of a new therapeutic tool against cancer stem-like cells ! |
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23/11/2021 - [Congratulations Alain!]
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Congratulations to Alain who received 2 prices. The Seqens price of the French Academy of Science and the Berthelot medal for his contribution on the development of novel strategies in the use of chemical reactions in biological media for the manipulation of living systems ! The team is really proud of you for all these great achievements ! TOUTES NOS FELICITATIONS ALAIN ! |
19/11/2021 - [Congratulations Victor!]
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Congratulations to Victor Lehot who passed his PhD defense successfully in front of a jury composed of Prof Mélanie Etheve-Quelquejeu, Prof Kurt Gothelf and Dr Yasuhiro Matsumura ! We are really proud of him and wish him the best for his future career on the USA! |
17/11/2021 - [New publication!]
Congratulations to Tony Rady and all the people involved on this publication about the synthesis of an oxidized analogue of BCN alcohol : the BCN acid !
This new BCN acid can be easily functionnalized via amide bond formation yields more stable derivates than the classically encountered carbamates.
We showed that it shared a similar reactivity with its primary alcohol derivative for SPAAC or IEDDA reactions, and that its facile activation to an activated ester allows the effective synthesis of immunoconjugates.
Don't hesitate to read the paper : pubs.rsc.org/en/content/articlelanding/2021/ra/d1ra07905k
28/10/2021 - [Meet Alain at the "Technologies and Diagnostic for Drug Development" workshop organized by the IMS!]
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Meet Alain on November 8th at the 2021 workshop of the IMS about "Technologies and Diagnostic for Drug Development". He will give a talk about the opportunities and challenges of single cell secretion! |
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06/10/2021 - [WELCOME!]
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We are happy to welcome Dr Abhaya K Mishra, a post-doc from the team of Prof. Jerome Waser at the LCSO, EPFL (Switzerland)! Drawing from the expertise of our two groups, he will test his compound in an effort to develop novel protein conjugation method! He will stay with us for a two-week period time! |
06/10/2021 - [WE ARE HIRING!]
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Our team is looking for a competent and highly motivated biological engineer to work on the development of biological methods for the study of new cleavable linkers ! Find more details in the descriptions :
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05/10/2021 - [WELCOME!]
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Welcome to our new PhD student , Safae Mouftakhir (University of Grenoble-Alpes)! She is in collaboration with the team of Michael Ryckelynck (https://ibmc.cnrs.fr/laboratoire/arn/equipes/biologie-digitale-de-larn/)! Good luck! |
29/09/2021 - [MicroOmix reporting presentation!]
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Do you want to learn more about our newest start-up MicroOmix ? In collaboration with the University of Strasbourg, we made a reporting video about the origin and the aim of the company ! You can watch this video in the following link : https://recherche.unistra.fr/actualites-recherche/actualites-de-la-recherche/microomix-de-la-recherche-a-la-start-up |
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06/09/2021 - [Welcome!]
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Welcome to Dr Ondrej Lidicky, a post-doc from the Institute of Macromolecular Chemistry (IMC) of Prague ! Drawing from the expertise of our two groups, he will develop novel antibody-polymer conjugates for targeted drug delivery to cancer cells until December ! |
19/08/2021 - [MicroOmix started its independant activities!]
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Congralutations to MicroOmix, our newest start-up hosted at BFC lab, who started its independant activities ! To celebrate it, the newpaper "l'Alsace" published an article to give an overview of the compagny's new technology ! |
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30/06/2021 - [WE ARE HIRING!]
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Our team is looking for a competent and highly motivated synthetic chemist for a PhD project in the field of microfluidics at the interface of chemistry and biology ! Find more details in the descriptions :
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04/06/2021 - [Start-up creation!]
After more than eight years of join research with the team of Michael Ryckelynck (https://ibmc.cnrs.fr/laboratoire/arn/equipes/biologie-digitale-de-larn/) we are happy to announce the creation of our newest start-up MicroOmiX (https://microomixtech.com). By converting microfluidic droplets into ultrasensitive sensors, the company provides a resolutive high-throughput single-cell secretome analysis and sorting technology. We expect it to have a major impact in the field of therapeutic antibody, regenerative medicine and stem cell biology. The early development of this technology was supported by l'Institut du Medicament de Strasbourg IMS (https://iti-ims.unistra.fr) and SATT Conectus (https://www.conectus.fr).
31/05/2021 - [WE ARE HIRING!]
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Our team, in partnership with Sanofi (Vitry-sur-Seine), is looking for a competent and highly motivated master student for a PhD position in the field of organic chemistry applied to protein bioconjugation ! Find more details in the descriptions :
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10/04/2021 - [Meet Tony at the American Association for Cancer Research virtual meeting 2021!]
Tony is presenting a poster at the American Association for Cancer Research virtual meeting 2021 !
Don't hesitate to see his work about antibody-siRNA conjugates here !
Don't hesitate to see his work about antibody-siRNA conjugates here !
06/04/2021 - [Welcome!]
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Welcome to our new post-doc, Dr Héloïse Cahuzac ! |
05/02/2021 - [Congratulations Charlotte!]
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Congratulations to Charlotte Sornay who passed her PhD defense successfully in front of a jury composed of Dr Sarah Cianférani, Prof Sébastien Papot, Prof Gonçalo Bernardes and Prof Jieping Zhu ! We are really proud of her and wish her the best for her future career! |
25/01/2021 - [Welcome!]
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Welcome to Dumitru (University of Strasbourg), our new trainee ! |
08/01/2021 - [Meet Guilhem at the 2021 Chemical Biology and Bio-Organic Group Forum]
Meet Guilhem on January 8th at the 2021 Chemical Biology and Bio-Organic Group Forum. He will give a talk about "Investigating multicomponent approaches for the site-selective conjugation of native antibodies" !
14/12/2020 - [WE ARE HIRING!]
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Our team is looking for a competent and highly motivated synthetic chemist for a post-doctoral position in the field of organic chemistry applied to protein bioconjugation ! Find more details in the descriptions :
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11/12/2020 - [Congratulations Guilhem!]
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Congratulations to Guilhem Chaubet who successfully defended his "Habilitation à diriger des recherches" in front of a jury composed of Dr Sarah Cianférani, Dr Sandrine Sagan, Dr Didier Boturyn, Prof Christian Hackenberger and Prof Jérôme Waser ! Good luck in your future projects ! |
19/10/2020 - [New microfluidic room!]
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Our new microfluidic room is ready! Time to make some droplets! |
01/10/2020 - [WELCOME!]
Welcome to our new PhD students, Valentine Vaur (University of Strasbourg), Lorenzo Turelli (Unilever, UK), Ilias Koutsopetras (Syngenta, CH), Robin Dufossez (University of Lille) and Jessica Coulleray (University of Montpellier). Good luck !
23/06/2020 - [WE ARE HIRING!]
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Our team is looking for a competent and highly motivated synthetic chemist for a PhD project in the field of organic chemistry applied to protein bioconjugation ! Find more details in the descriptions :
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15/06/2020 - [Our lab renovation work is done!]
16/04/2020 - [WE ARE HIRING]
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In the context of a project funded by the European Commission (European Training Network), our group and 8 other partners are recruiting 11 PhD students, to work at the interface of chemistry and biology, for the development of new targeted anti-cancer therapies.
Find more details in the description or on the website: http://tact-etn.eu
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01/03/2020 - [Congratulations!]
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‘Targeted Anti-Cancer Therapies’ (TACT) is a ‘European Training Network’ (ETN) research project that received funding by the European Commission under the ‘Horizon 2020 research and innovation programme’ and the ‘Marie Skłodowska-Curie actions’. The TACT project results from the collaboration between six universities and three companies located in five different European countries and aims to train early-stage PhD students in the development of state-of-the-art targeted anti-cancer therapeutics.
This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under the Marie Skłodowska Curie Action Grant Agreement No 859458. http://tact-etn.eu |
22/01/2020 - [Meet Charlotte at the International Symposium on Chemical Biology - Geneva!]
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Meet Charlotte at the 2020 International Symposium on Chemical Biology organized by NCCR Chemical Biology ! She will present a poster explaining her approach for the site-selective modification of antibodies on Thursday and Friday! |
06/01/2020 - [Creation of the Strasbourg Interdisciplinary Drug Discovery and Development Institute]
13/12/2019 - [Meet Alain at the Faculty of Pharmacy - Illkirch-Graffenstaden!]
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Alain will give a talk on "BioFunctional Chemistry-based approaches toward alternative therapeutic strategies" during a chemical biology mini-symposium organized by the Klymchenko group. |
05/12/2019 - [Meet Charlotte at the Holtzheim library!]
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Meet Charlotte at the Holtzheim library on december the 5th at 8 pm. She will give a talk on "Cancers: actual and future therapies". Charlotte donnera une conférence à la médiathèque d'Holtzheim le 5 décembre à 20 h. La conférence traitera du cancer et des thérapies actuelles et futures, et sera tout public. Venez nombreux ! |
25/11/2019 - [Welcome!]
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Welcome to Ketty, our new research engineer ! |
07/11/2019 - [Meet Alain at Syngen Series UK 2019 - London, UK]
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Meet Alain at the 7th annual single cell analysis congress on november 7th ! He will give a talk on "droplet microfluidic-based single cell secretomic analysis" ! |
18/10/2019 - [Internship projects 2020]
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We are looking for two highly motivated master students who wish to do their master project at the interface of chemistry and biology.
One project will aim to design new strain alkynes and then test their reactivity in SPAAC. The second project will imply the synthesis of unnatural retinoids to discover what the active form of vitamin A is in vivo; This project has already received a funding from the Agence Nationale de la Recherche for a PhD, which could be attributed to the student in case of fruitful results. You will find more details about the two internships in the following offers. | ||||
12/10/2019 - [Fête de la science 2019]
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Meet us on Saturday and Sunday at la Fête de la Science in Strasbourg! Charlotte will present her thesis in 180 seconds and show you how to create an efficient army against cancer! |
01/10/2019 - [Welcome!]
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Welcome to our new PhD students, Enes Dursun (University of Montpellier) and Julien Most (University of Strasbourg)! Good luck! |
23/09/2019 - [Meet Alain and Igor at the 6th Barrande Bioscience Meeting - Strasbourg, France]
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Alain will give a talk on September 23rd on « Low Conversion Chemistry for Stoechiometric Bioconjugation » Igor will present a poster untiltled « Automated one-to-one linkage of proteins and payload » |
19/08/2019 - [WELCOME!]
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Welcome to our new post-doc, Dr Patrick Neuberg! |
18/07/2019 - [WE ARE HIRING]
Two PhD positions are opened at the BFC group! Find more details in the descriptions :
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02/07/2019 - [Meet Alain at "Meet & Match: Precision Medicine" in Stuttgart]
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Alain gave a talk on « Microomix: single cell secretomic - the next frontier in the dynamic tumor heterogeneity? » |
11/06/2019 - [Meet Alain at the BIOTechnoAuRA !]
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Meet Alain Wagner on June 11th at the Forum BIOTechno Auvergne-Rhône-Alpes ! He will share his experience in the 1st plenary conference: « Comment créer et gérer sa start-up » ! |
06/06/2019 [Chemistry Football Tournament « Daniel Martina » 2019]
Thursday, June 6th, on the grounds of Illkirch campus, the traditional football tournament was held, with the participation this year of 22 teams. The motivated and over-trained mixed team of UMR7199/7200, Syndivia and Illkirch techninal service won the tournament this year!
Congrats to Fabien H, Mickael R, Romuald, Nicolas G, Clément, Charlotte, Logan, Damla, Guilhem, Nicolas W, Mickael C, Sébastien, Laura, Catherine, Nunzio and Fabien T!
Congrats to Fabien H, Mickael R, Romuald, Nicolas G, Clément, Charlotte, Logan, Damla, Guilhem, Nicolas W, Mickael C, Sébastien, Laura, Catherine, Nunzio and Fabien T!
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04/06/2019 - [Meet Alain at the Génération Start-up workshop !]
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Meet Alain at a workshop organized by Génération Start-up at the Pôle API ! |
03/06/2019 [Conference Prof. Youhei Sohma]
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Thanks to Prof. Youhei Sohma, from the University of Tokyo, for the conference he gave on June 3rd on the photoactivable oxygenation catalysts of Amyloids |
20/05/19 - [Meet Alain at the 27th French-Japanese Symposium !]
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Meet Alain at the 27th French-Japanese Symposium on Medicinal and Fine Chemistry in Fukuoka (Japan). He will give a talk on the 20th of May on "Interfacing living and synthetic systems at molecular level"! |
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13/05/19 - [Welcome!]
Welcome to Romain (University of Strasbourg), our new trainee !
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02/05/19 - [Meet Alain at the Upper Rhine Health Tech Innovation Forum!]
Meet Alain at the Upper Rhine Health Tech Innovation Forum on the 15th of May. He will give a talk on "Single-cell proteomic: from a MEDALIS research project to a startup company" !
26/04/19 - [Congratulations!]
Congratulations to our intern Julien and Agathe who won the DDD Challenge organized by Medalis !
As a reward, Julien and Agathe’s PhD thesis will be funded by Medalis! See you Julien in October for the beginning of your PhD!
26/04/19 - [Meet Alain and Sylvain at the 7th MEDALIS meeting!]
Today, Alain and Sylvain presented the MicroOmix technology at the 7th MEDALIS public scientific meeting
09/04/19 - [Congratulations !]
We are pleased to announce that Elisabetta Tobali, our fellow PhD, graduated on April, 9th 2019, with a thesis entitled :
" Acid catalyzed abiotic reactions in biological systems :
from design to in vivo proof of concept "
03/04/19 - [MicroOmix]
MicroOmix is selected for the national phase of the i-lab innovation contest !
More information about MicroOmix at microomixtech.com
More information about MicroOmix at microomixtech.com
03/04/19 - [Meet Sergii at PEGS Boston 2019 !]
Meet Syndivia’s CSO, Dr Sergii Kolodych, at PEGS Boston 2019 and catch a glimpse of our latest developments in the field of native protein conjugation on April 11 at Seaport World Trade Center, Boston, MA.
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Laura Descamps
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01/04/19 - [Welcome !]
Welcome to our new trainee, Laura (University of Lille) !
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28/03/19 - [MT180]
Congratulation to Charlotte for her performance at "My thesis in 180 seconds" ! Good luck to Farah Bouhedda (IBMC) and Blandine Chazarin (IPHC) for the final next week ! |
MT180 participants
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Charlotte Sornay
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Dr. Jean-Serge Remy
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09/03/19 - [Congratulations !]
Congratulations to Jean-Serge Remy for his promotion as Research director 1st class !
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22/01/19 - [Meet Alain and Sylvain at Molecular Med Tri-Con 2019 !]
From the 10th to the 15th of Marc, meet Alain and Sylvain at Molecular Med Tri-Con 2019 in San Francisco, CA.
http://triconference.com
http://triconference.com
22/01/19 - [Meet Alain at ICRAMC-19 !]
From the 13th to the 15th of February, meet Alain at the 3rd International Conference on Recent Advances in Material Chemistry
Organized by the Department of Chemistry SRM Institute of Science and Technology Kattankulathur – 603 203
Organized by the Department of Chemistry SRM Institute of Science and Technology Kattankulathur – 603 203
Iryna Shcheholeva
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21/01/19 - [Welcome !]
Welcome to our new trainees, Iryna Shcheholeva (University of Lyon) and Julien Most (University of Strasbourg) !
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Julien Most
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Igor Dovgan
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[New Project!] October 2018 - September 2020
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BFC Group is proud to announce a new collaboration with Dr. W. Krewel (IGBMC - INSERM - UMR7104)
NEW APPROACH IN BIOORTHOGONAL CHEMISTRY FOR THE STUDY OF BIOACTIVE MOLECULES IN VIVO
Although recent developments in dedicated analysis technologies facilitate the identification and study of small bioactive molecules, researchers face difficulties with the scanty molecules, detection problems or instability of certain categories of molecules.
This project brings together various expertise in biology and chemistry to validate a new method of integrative multi-level analysis of small molecules in a complex biological environment. This method is based on a highly biospecific reaction, which we have recently demonstrated to be effective in targeting an exogenous molecule in vivo. We propose today to apply this new approach to small bioactive endogenous lipids using chemiospecific probes, thus determining metabolic fate, identifying relevant metabolic enzymes and receptors, and controlling bioavailability. The data obtained should validate existing knowledge and provide answers to the open questions of biology, while opening new avenues for questioning the physiology and pathology of biological processes. |
Dr. Wojciech Krezel
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17/07/18 - University of Strasbourg starts to renew its facilities, including our labs.
Stay tuned for more info!
05/07/18 - A PhD and a Post-Doc positions are opened at the BFC group.
Find more details in the descriptions.
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[05/06/18 - UMR 7199/7200]
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Tournoi de football de la chimie
Daniel Martina" 2018 Ambiance sportive, festive et amicale sous le soleil ! Mardi 5 juin sur le terrain du campus d’Illkirch, s’est déroulé le traditionnel tournoi de football réunissant cette année une douzaine d’équipes. L’équipe mixte UMR 7199/7200, motivée et sur entrainée, a brillé sur les terrains en terminant demi-finaliste. Bravo Guilhem, Mickael, Fabien, Nicolas, Sébastien, Lucie, Laure, Mickael, Fabien et Léo! |
Chemistry Football Tournament
"Daniel Martina" 2018 Sporty, festive and friendly atmosphere under the sun! Tuesday, June 5th, on the grounds of Illkirch campus, the traditional football tournament was held, with the participation this year of 12 teams. The motivated and over-trained mixed team UMR 7199/7200 shone on the field, conquering the semi-finals. Congrats to Guilhem, Mickael, Fabien, Nicolas, Sébastien, Lucie, Laure, Mickael, Fabien and Léo! |
Chemistry & Football
31/05/18 - BFC team and SANOFI are looking for a PhD student (36 months) in the field of Organic Chemistry and Biology+Immunology.
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BFC's (non)scientific conferences #1
Meet and ask question to Vincent Gass, global head of marketing for the ICS business unit at Clariant, a 6 billion CHF revenues’ company, ranking among the largest providers of specialty chemicals and application solutions for consumer care and industrial markets.
16 years acumen in strategic marketing & business development with comprehensive exposure to specialty chemicals, pharmaceuticals and biotechnologies.
16 years acumen in strategic marketing & business development with comprehensive exposure to specialty chemicals, pharmaceuticals and biotechnologies.
[MEET US!]
Meet Alain WAGNER at PEGS Boston, May 2 Boston USA
http://www.pegsummit.com/Antibody-Drug-Conjugates/
Alain will present Chemical Fusion: A General Method for Equimolar Linking of Proteins and Payloads
[MEET US!]
Meet Sylvain URSUGUEI at TriCon Molecular Medicine, Feb 11-16 San Francisco USA
http://www.triconference.com
Sylvain will present a new approach for Deciphering cancer heterogeneity at the single cell multi-omic level.
[Congratulations!] |
Michel Mosser of BFC group has been promoted from "technician superior class" to "technician exeptional class" by the internal promotion of the CNRS for 2017.
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[Conference]
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BioFIT is proud to host LabEx Medalis for this edition in Strasbourg. The Drug research center Medalis is a “Laboratory of Excellence” (Labex) created in July 2011 as part of the French program “Investments for the Future”. It is a member of “Initiatives of excellence” (IDEX) in the University of Strasbourg. The aim of the company is to develop innovative drugs for cancer or inflammation treatment. On the 28th of November will be held 3 conferences introduced by LabEx Medalis: – Session 1: Translational research at Medalis: From lab to biotech – Session 2: Early projects, early opportunity: Find your match – Session 3: Nature and nurture of an Academic drug discovery Center |
18/10/2017
[BFC on press!]
Alain Wagner, Sylvain Ursuguei and Wojcioech Krezel (research director at INSERM - IGBMC) collabo-rated on an in vivo strategy to counteract post-administration anticoagulant activity of a specific drug.
The project, already published on Nature Communication, is object of an article on the Strasbourg local newspaper.
BFC group is pleased to contribute to the communication and popularization of Science. This work was already shared and commented by CNRS page, CNRS twitter page and BioCentury Journal. This is the first time the work appears in a general-audience newspaper, confirming the quality, relevance and importance of our research.
06/10/2017 [Conference]
BFC group welcomes Prof. Dr. Andreas Pahl, CSO of Heidelberg Pharma, who held a conference about Amanitin-based ADC. Take a look at the Youtube video below to catch a glimpse of the speech.
[Congratulations!]
Our team is pleased to announce that Eric Thomas, our fellow PhD student, graduated on September, 29th 2017 with a thesis entitled:
Stratégies de marquage chimiospécifique et bioorthogonale
pour l'analyse métabolomique des rétinoïdes
(Chemospecific and Bioorthogonal Labeling Strategies
for Metabolomic Analysis of Retinoids)
pour l'analyse métabolomique des rétinoïdes
(Chemospecific and Bioorthogonal Labeling Strategies
for Metabolomic Analysis of Retinoids)
[Congratulations!]
Our team is pleased to announce that Igor Dovgan, our fellow PhD student, graduated on September, 21st 2017 with a thesis entitled:
Antibody conjugates:
integrated approach towards selective, stable and controllable bioconjugation
integrated approach towards selective, stable and controllable bioconjugation
The BFC team was glad to welcome the members of the jury coming from University of Lille (France) and University College London (UK).
President:
Dr. Sarah Cianferani (Université de Strasbourg)
Members:
Dr. Vijay Chudasama (UCL, London, UK)
Prof. Christophe Biot (Université de Lille 1)
Dr. Alain WAGNER
Dr. Sergii Kolodych
President:
Dr. Sarah Cianferani (Université de Strasbourg)
Members:
Dr. Vijay Chudasama (UCL, London, UK)
Prof. Christophe Biot (Université de Lille 1)
Dr. Alain WAGNER
Dr. Sergii Kolodych
[Conferences]
Save the date for the next two conferences organized by our research unit (UMR 7199).
Meet Alain Wagner
BFC's director Dr. Alain Wagner will talk about "Chemoselectivity in biological media" this next Thursday, September 14th, @ University of Grenoble Alpes.
[Congratulations!]
Our team is pleased to announce that Zoljargal Baatarkhuu, our fellow PhD student, graduated on September, 4th 2017 with a thesis entitled:
Metabolic labelling of bacterial isoprenoids produced by the methylerythritol phosphate pathway: A starting point towards a new inhibitor
The BFC team was glad to welcome the members of the jury coming from University of Nice and ICSN-CNRS in Paris.
President:
Professor Alain BURGER (Institut de Chimie, Université de Nice, UMR 7272)
Members:
Dr. Joelle DUBOIS (Directeur de recherche, ICSN - CNRS, Paris)
Dr. Myriam SEEMANN (Directeur de recherche, Institut de chimie, Université de Strasbourg, UMR 7177)
Dr. Alain WAGNER
President:
Professor Alain BURGER (Institut de Chimie, Université de Nice, UMR 7272)
Members:
Dr. Joelle DUBOIS (Directeur de recherche, ICSN - CNRS, Paris)
Dr. Myriam SEEMANN (Directeur de recherche, Institut de chimie, Université de Strasbourg, UMR 7177)
Dr. Alain WAGNER
25/07/17 - BFC team is looking for a PhD student (36 months) in the field of Bioconjugation and Antibody-Drug Conjugates.
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BFC takes part in the ESMEC Summer School
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BFC in BioCentury!
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BioCentury's weekly flagship publication provides analysis, interpretation and commentary on biopharma industry corporate performance, product discovery and development, emerging companies and technology, public policy, regulatory events and innovation and financial markets. (Source here)
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From the article
A new study has discovered an in vivo use of click chemistry that can rapidly clear drugs from circulation in case of emergency. [...] Last month in Nature Communications, a team from University of Strasbourg [...] used a bioorthogonal reaction -- described as "click and clear" -- to neutralize a modified version of warfarin in vivo and rapidly remove it from circulation.
[...] Study author Alain Wagner told BioCentury the method is versatile and can be applied to a wide range of molecules. "We designed the experiments to show we could do chemical transformation directly in the living organism. The anti-coagulant drug is an example of what you can do, but it's just one application among others" he said.
He said his team is building a library of bioorthogonal reactants that can be used to either clear or inactivate a wide range of drugs and metabolites. Wagner is research director at Centre National de la Recherche Scientifique (CNRS) in the Laboratory of Biofunctional Chemistry at University of Strasbourg.
"The future is to extend this to other types of exogenous and endogenous compounds," said co-author Wojciech Krezel, a research director at Institut National de la Santé et de la Recherche Médicale (INSERM) in the Institute of Genetics and Molecular and Cellular Biology (IGMBC).
A new study has discovered an in vivo use of click chemistry that can rapidly clear drugs from circulation in case of emergency. [...] Last month in Nature Communications, a team from University of Strasbourg [...] used a bioorthogonal reaction -- described as "click and clear" -- to neutralize a modified version of warfarin in vivo and rapidly remove it from circulation.
[...] Study author Alain Wagner told BioCentury the method is versatile and can be applied to a wide range of molecules. "We designed the experiments to show we could do chemical transformation directly in the living organism. The anti-coagulant drug is an example of what you can do, but it's just one application among others" he said.
He said his team is building a library of bioorthogonal reactants that can be used to either clear or inactivate a wide range of drugs and metabolites. Wagner is research director at Centre National de la Recherche Scientifique (CNRS) in the Laboratory of Biofunctional Chemistry at University of Strasbourg.
"The future is to extend this to other types of exogenous and endogenous compounds," said co-author Wojciech Krezel, a research director at Institut National de la Santé et de la Recherche Médicale (INSERM) in the Institute of Genetics and Molecular and Cellular Biology (IGMBC).
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22/06/17 - BFC group is looking for a Post-Doc (18 months) in the field of Bioconjugation and Antibody-Drug Conjugates.
25/07/17 The position has been filled | ||
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20/06/17 - BFC's and IGBMC's last discovery is now available on Nature Communications and on the official CNRS site!
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Click on the icons to visit the official pages of CNRS!
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Neutraliser un médicament dans l’organisme pour stopper ses effets secondaires @unistra @NatureComms #sante https://t.co/wCjuXy3o9P pic.twitter.com/UCDU8dKobw
— Chimie au CNRS (@INC_CNRS) 20 giugno 2017
The BFC team is pleased to welcome
Professor Sunjoo Jeong, Director of the Institute of the Institute of Convergence Studies, Dankook University Korea and Professor Jaehoon Yu, Department of Chemistry & Education, Seoul National University
MPX: Fighting Cancer at the Unique Cell ScaleHow to fight cancer cells more effectively? Three laboratories have put their expertise together to provide a new way of answering this question. The Laboratory of Design and Application of Bioactive Molecules (UMR 7199), the Laboratory Architecture and Reactivity of RNA, and the Laboratory Targeted Therapies of the Microenvironment Tumor, have joined forces to give birth to the MPX project, a new development in microfluidics. Ketty Pernod and Sylvain Ursuegui, the two promoters of the project, explain their approach in this short video.
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BFC in press!
Welcome!Welcome to Guilhem Chaubet who joined BFC group in January 2017 as CNRS Researcher to investigate new site-specific bioconjugation strategies.
Guilhem was born in Avignon, France, and completed his undergraduate and PhD degrees in Montpellier in the group of Prof. Jean Martinez. His research activities focused on ring-contraction reactions and their use for the synthesis of organized edifices, such as foldamers. He then started a postdoc in the Ed Anderson group at the University of Oxford where he worked on the total synthesis of rubriflordilactone, on the synthesis of new phosphoramidite ligands for rhodium-catalysis and on the development of a new approach to access heteroaromatics using palladium-catalysis.
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Congratulations!In 2016, the Pierre FABRE Award for Therapeutic Innovation goes to Dr. Alain Wagner. |
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Innovation recognitionConectus Alsace licenses to Syndivia an original technology arising from BFC's research in the field of Antibody Drug Conjugate |
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